I use a Cannon r5 mark ii with a few different lenses and a fujifilm x100vi. Both the fuji and the Cannon with a 50mm lense mounted + RF 24-70mm lense fit there perfectly.
I just used the bag for 10 days straight on a trip with an avarage of 5-6 hours of walking a day. It is very comfortable. The only improvement I would suggest is a bit more padding on the shoulder because in certain positions the bag start to irritate but nothing major.
Insulation is perfect. I was rained on twice on the trip and the bag stayed perfectly dry.
I think this size is perfect even if you don't have a large setup. I had my wallet, car keys, pill box, and some film canisters in there as well and it all fit great.