Took this on a recent multi-stop agricultural work trip in the United States: 5 days, two flights, three rental cars, 5 states, 5 different hotels. Took this as my sole bag, carry-on style. Didn't have a problem carrying on with Southwest or Delta - for great in the overhead bins. Granted, I didn't have the bag stuffed to absolute capacity, and I removed the waist strap.
Loved that I could carry my laptop along with clothes and other necessities. When I first received the bag, it seemed like there was maybe too much going on - too many zippers, access points, etc. I actually ended up loving that I could access pretty much anything in the bag, anywhere, without removing anything else. Materials seem top notch. Looking forward to many more trips with this one.